Expert Insights in IgAN
Drs Lerma, Kalra, and Colbert share perspectives on pathophysiology, diagnosis, treatment goals, and emerging therapies
Expert Perspectives
Clinical Perspectives
Hear directly from experienced IgAN clinicians as they share real-world insights, treatment considerations, and lessons learned from supporting patients in daily practice.
VIDEODisease Burden
Discover how the burden of IgAN, including the likelihood of progression to kidney failure within 10–15 years, can significantly affect patients’ mental and emotional well-being.
VIDEOPathophysiology
Explore the role of APRIL in B-cell development and IgAN pathogenesis, and learn how a better understanding of IgAN pathophysiology allows for a more targeted management approach.
VIDEOUrgency to Treat
Explore how early detection and diagnosis of IgAN can support timely treatment and help reduce the risk of disease progression.
VIDEOCurrent Management
Learn about the current strategies for the management of IgAN and the ongoing need for therapies that target the underlying causes of IgAN.
Expert FAQs
Frequently Asked Questions
Get answers to the most frequently asked questions from healthcare professionals like you. Our experts break down key topics in IgAN with clarity and clinical relevance.
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- Mechanism of Disease /
- Disease Burden and Progression /
- Disease Management
VIDEO4-Hit Process
Join Dr Lerma as he outlines the role of the 4-hit process in IgAN pathogenesis.
VIDEOAPRIL
Discover with Dr Lerma how APRIL acts as a key driver of IgAN pathogenesis.
VIDEOProteinuria
Gain insight into target proteinuria thresholds and their relevance in IgAN management from Dr Colbert.
VIDEOTreatment Landscape
Explore the evolving treatment landscape of IgAN with Dr Colbert.
VIDEOGaps in Treatment
Examine gaps in the current IgAN treatment landscape with Dr Colbert.
VIDEOPrognostic Tools
Learn from Dr Lerma about the MEST-C score and how it is used to assess the risk of IgAN progression.
VIDEOPatient Presentation
Gain insight from Dr Colbert into how patients with IgAN typically present in the clinic.
VIDEOQuality of Life
Explore the impact of IgAN on a patient’s mental and emotional health with Dr Kalra.
VIDEOBiopsy
Hear Dr Kalra’s guidance on when to biopsy patients.
APRIL, a proliferation-inducing ligand; IgAN, IgA nephropathy; MEST-C, mesangial hypercellularity (M), endocapillary hypercellularity (E), segmental sclerosis (S), tubular atrophy and interstitial fibrosis (T), crescent (C).