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Screening & Differential Diagnosis For Autosomal Dominant Polycystic Kidney Disease (ADPKD)

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Screening & Differential Diagnosis For Autosomal Dominant Polycystic Kidney Disease (ADPKD)

In most cases of ADPKD, the diagnosis is straightforward, with patients presenting with enlarged cystic kidneys and a positive family history.1 However, in some cases, the diagnosis can be a bit more complicated. A small number of cases (~5%) occur due to spontaneous (de novo) mutations,2 but a lack of family history is reported in as many as 25% of newly diagnosed cases, suggesting that many familial cases go undetected.2 Additionally, there are several rare conditions that can present with cystic kidneys and may be considered during the differential diagnosis of ADPKD.1  
Why watch this webinar?
Expert speakers will discuss a diagnostic work up for ADPKD and walk through a diagnostic algorithm including a differential diagnosis for cystic kidney disease. Best practices for different imaging modalities and genetic testing will be reviewed.  
What you will learn:
  • When to utilize different imagining modalities for diagnosis and prognosis of polycystic kidney disease
  • When it may be appropriate to incorporate genetic testing
  • If not ADPKD, then what could it be?
  • Best practices for obtaining the most accurate results for patients


Ranine Ghamrawi

Ranine Ghamrawi, MD


Nephrology Associates, PA*

Dr Ghamrawi is currently a practicing nephrologist in Delaware with Nephrology Associates, PA., the largest single specialty practice caring for patients with kidney disease and hypertension in the State of Delaware and Cecil County, MD. Dr Ghamrawi completed her nephrology fellowship at Mayo Clinic, Rochester, Minnesota. She also completed certificate of clinical and translational science at the Mayo Clinic, Rochester, Minnesota. Prior to that, she completed her internal medicine residency at Michigan State University/ Hurley Medical Center. She has numerous publications particularly centered around preeclampsia, hypertensive disorders of pregnancy and PKD. She is also an ad-hoc reviewer for Hypertension in Pregnancy. Her areas of interest include hypertensive disorders of pregnancy, Polycystic kidney disease and Onco-nephrology.

Edgar Lerma

Edgar Lerma, MD

Clinical Professor of Medicine

University of Illinois at Chicago*

Edgar Lerma, MD, earned his Doctor of Medicine from the University of Santo Tomas Faculty of Medicine and Surgery in Manila, Philippines. He completed Residency Training in Internal Medicine at UIC/Mercy Hospital and Medical Center, where he also served as Chief Resident. He completed a Fellowship in Nephrology and Hypertension at Northwestern Memorial Hospital, the Feinberg School of Medicine at Northwestern University, and the Veterans Administration Lakeside Medical Center in Chicago, Illinois.
Dr. Lerma is a Diplomate in the Subspecialty of Nephrology with the American Board of Internal Medicine. He has authored more than 100 peer-reviewed publications and presentations; notable publications include Current Diagnosis & Treatment: Nephrology & Hypertension, Nephrology Secrets, and Henrich’s Principles and Practice of Dialysis. He has peer reviewed and served on editorial boards for numerous journals, and currently is Associate Editor for International Urology and Nephrology, Clinical Reviews in Bone and Mineral Metabolism, and Journal of Clinical Lipidology. At present, he holds the rank of Clinical Professor of Medicine with the Section of Nephrology at University of Illinois at Chicago. He serves as the Educational Coordinator for Nephrology with UIC/Advocate Christ Medical Center.
In recognition of his clinical work and expertise, Dr. Lerma has been elected to Fellowship of the American College of Physicians, Fellowship of the American Society of Nephrology, Fellowship of the American Heart Association/ Council on Kidney in Cardiovascular Disease, Fellowship of the American Society of Hypertension, Fellowship of the National Lipid Association, Fellowship of the National Kidney Foundation, and Fellowship of the American Society of Diagnostic and Interventional Nephrology. He has also been recognized for teaching and has been the recipient of “Subspecialty Teaching Attending Physician of the Year” in 2006 and “Physician Recognition Award for Excellence in Academics” in 2011 from UIC/Advocate Christ Medical Center Internal Medicine Residency Training Program.
Dr. Lerma’s research interests include CKD, hypertension, bone and mineral disorders, and dyslipidemias in CKD.


Kelly Reed

Kelly Reed, PhD

Nephrology Senior Medical Science Liaison

Otsuka Pharmaceutical Development & Commercialization, Inc.*

Kelly Reed, PhD, joined Otsuka in 2012 and is currently a Senior Medical Science Liaison on our Nephrology East Team. Dr Reed has collaborated with several national professional organizations and healthcare systems providing educational presentations on hyponatremia and Autosomal Dominant Polycystic Kidney Disease (ADPKD). She has been a leader in resource development for the MSL team, co-led the nephrology MSL new hire training program during expansion and served as a mentor to several MSL new hires. Dr Reed earned her doctorate from Virginia Commonwealth University in Richmond, Virginia and completed her clinical internship at the Mailman Center for Child Development in Miami, Florida, followed by a two year fellowship at Cincinnati Children’s Hospital Medical Center.

*Drs Ranine Ghamrawi and Edgar Lerma are paid consultants of Otsuka Pharmaceutical Development & Commercialization, Inc. (OPDC). Dr Kelly Reed is an employee of OPDC.

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