following is a summary of
Chapman A et al. Kidney Volume and Functional Outcomes in Autosomal Dominant
Polycystic Kidney Disease. CJASN. 2012;7(3):479-86, which was
developed independently of the article authors.
Autosomal Dominant Polycystic Kidney Disease (ADPKD) can be
described as the formation and expansion of cysts.
Cyst formation and expansion within both kidneys, leads to
enlarged kidneys and a gradual increase in total kidney volume (TKV) over a
TKV increases generally precede detectable changes in kidney
function decline by decades.
As total kidney volume is considered an early marker …
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