Hot Topics in Nephrology: Taking a Deeper Dive into the 4-Hit Cascade in IgA Nephropathy – The Role of APRIL
Welcome to NephU’s Hot Topics in Nephrology Series featuring various experts in the field of nephrology. In this podcast series, thought leaders will share their expertise and perspectives on the latest developments and trends in the nephrology space.
Background:
IgA Nephropathy is the most common primary glomerulonephritis in the world. It is widely accepted that multiple hits must occur for IgA Nephropathy to develop. This “four-hit cascade” includes an increase in circulating galactose-deficient IgA1 (Gd-IgA1) (hit 1), autoantibody generation against Gd-IgA1 (hit …